Publications

2021

Lamb MC, Kaluarachchi CP, Lansakara TI, Lan Y, Tivanski AV, and TL. Tootle.  Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration. BioRxiv. doi.org/10.1101/2021.04.27.441651

 

 

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Palacios V, Kimble G, Tootle TL, and Michael Buszczak. (2021) Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells. JCS. 134(7):jcs258391 doi:10.1101/2020.02.10.942326

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2020

Lamb M.C. and T.L. Tootle. (2020) Fascin in Cell Migration: More Than an Actin Bundling Protein. Biology.  9:403. doi:10.3390/biology9110403

Green N.M.*, Kimble G.C.*, Talbot D.E.* and T.L. Tootle. (accepted) Nuclear Actin. eLS,  1: 1–12. doi: 10.1002/9780470015902.a0028471

Fox E.F., Lamb M.C*., Mellentine S.Q*. and T.L. Tootle. (2020) Prostaglandins regulate invasive, collective border cell migration. MBoC. 15: 1584-1594. doi:10.1091/mbc.E19-10-0578

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Lamb M.C., Anliker K.K., and T.L. Tootle. (2020) Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo. Developmental Dynamics. 249: 961-982. doi:10.1002/dvdy.186

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FitzSimons M., Beauchemin , Kelpsch D., Lamb M., Tootle, T.L., and Yin, V. (2020) Cardiac injury modulates critical components of prostaglandin E2 signaling during zebrafish heart regeneration. Scientific Reports. 10: 3095. doi:10.1038/s41598-020-59868-6

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Duan T., Green N.M., Tootle, T.L., and P Geyer. (2020). Nuclear architecture in Drosophila female GSCs. Current Opinion in Insect Science. Invited Review. 37: 30-38. doi: 10.1016/j.cois.2019.11.007

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Palacios V., Kimble G.C., Tootle T.L., and M Buszczak. (submitted) Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells. BioRxiv: https://doi.org/10.1101/2020.02.10.94232

2019

Spracklen A.J., Lamb M.C., Groen C.M., and T.L. Tootle. (2019) Pharmaco-genetic screen to uncover actin regulators targeted by prostaglandins during Drosophila oogenesis. G3. https://doi.org/10.1534/g3.119.400704

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Tootle T.L., Hoffmann D., Allen A., Spracklen A., Groen C., and D Kelpsch. (2019) Mini-course based undergraduate research experience: Impact on student understanding of STEM research and interest in STEM programs. Journal of College Science Teaching. 48:44-54

2018

Wineland D*, Kelpsch D*, Tootle TL. (2018). Multiple pools of nuclear actin. The Anatomical Record. 301(12):2014-2036.

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Kelpsch D, Tootle TL. (2018). Nuclear actin: from discovery to function. The Anatomical Record. 301(12):1999-2013

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2017

Article about the lab:

2017. Understanding development and disease: prostaglandins coordinate actin cytoskeletal remodeling.  Research Features 110: 26-29.

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2016

Jayo A, Malboubi M, Antoku S, Chang W, Ortiz-Zapater E, Groen C, Pfisterer K, Tootle T, Charras G, Gundersen G.G., Parsons M. 2016. Fascin Regulates Nuclear Movement and Deformation in Migrating Cells. Dev. Cell. 38:371-383.

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Kelpsch DJ, Groen CM*, Fagan TN*, Sudhir S, Tootle TL. 2016. Fascin regulates nuclear actin during Drosophila oogenesis. MBoC. 27:2965-297.

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2015

Spracklen AJ, Tootle TL. 2015. Drosophila – a model for studying prostaglandin signaling. Bioactive Lipid Mediators: Current Reviews and Protocols. Springer Japan. Editors: Takehiko Yokomizo and Makoto Murakami.

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Groen CM, Tootle TL. 2015. Visualization of Actin Cytoskeletal Dynamics in Fixed and Live Drosophila Egg Chambers. Drosophila oogenesis: Methods and Protocols. Springer Methods Mol Biol. Editors: Diana Bratu and Gerard McNeil. 1328:113-24.

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Groen CM, Jayo A, Parsons M, Tootle TL. (2015) Prostaglandins regulate Fascin localization to the nucleus and function in nucleolar architecture. MBoC. 328:113-24.

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2014

Spracklen AJ, Fagan TN, Lovander KE, Tootle TL. (2014)  The pros and cons of common actin labeling tools for visualizing actin dynamics during Drosophila oogenesis. Dev. Biol. 393(2):209-26.

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Spracklen AJ, Kelpsch DJ, Chen X, Spracklen CN, Tootle TL. (2014) Prostaglandins temporally regulate cytoplasmic actin bundle formation during Drosophila oogenesis. MBoC. 25(3):397-411.

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2013

Spracklen AJ, Tootle TL. (2013) The utility of stage-specific mid-to-late Drosophila follicle isolation. J Vis Exp. 2013 Dec 2;(82). doi: 10.3791/50493.

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Tootle TL. (2013) Genetic insights into the in vivo functions of prostaglandin signaling. Int J Biochem Cell Biol. 45(8):1629-32.

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2012

Groen CM*, Spracklen AJ*, Fagan TN, Tootle TL (2012) Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling. MBoC. 23(23)4567-4578.

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2011

Tootle TL, Williams D, Hubb A, Frederick R, Spradling A (2011) Drosophila eggshell production: identification of new genes and coordination by Pxt. PLoS One 6: e19943.

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2008

Tootle TL, Spradling AC (2008) Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation. Development 135: 839-47

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*Authors contributed equally.